Dentistry is a peer-reviewed medical journal that publishes articles in a variety of fields, including endodontics, orthodontics, dental implants, prosthodontics, restorative dentistry, oral and maxillofacial surgery, periodontics, forensic dentistry, digital dentistry, and minimal intervention dentistry, among others, and provides a platform for authors to contribute to the journal. Peer review of the submitted articles is guaranteed by the editorial office to ensure high-quality publication.

A chronic inflammatory condition called periodontitis, it is a major factor in the degeneration of the tissues that support teeth. Periodontal disease rarely advances and does so episodically in most people. Healthy gingiva changes from gingivitis to periodontitis throughout the progression of periodontal disease. Periodontitis affects some people more than others. Recurrent periodontal disorders affect 30% of cases. Therefore, diligent patient observation is required to spot problem areas before more tissue damage occurs. To distinguish between disease locations that are active and inactive at the moment, clinical, microbiologic, and radiographic data are employed to identify early symptoms of disease activity. All of these diagnostic techniques have one drawback, though, which is that it is impossible to predict when healthy gingiva will turn into gingivitis and when gingivitis will turn into periodontitis. This hinders efforts to diagnose the illness and forecast future disease locations from both the clinical and research perspectives. Therefore, a problem unique to the discipline of periodontics is the difficulty to spot areas that are already degrading and at risk of being destroyed in the future as well as patients who are particularly vulnerable. Changes in the immune system carried by periodontitis include the infiltration of the tissues by neutrophils, macrophages, B cells, and T cells as well as the local production of high concentrations of cytokines and other mediators. The soluble proteins known as cytokines attach to particular receptors on target cells to initiate and stop intracellular signaling cascades. T cells contribute significantly to the control of the immune response at the site of inflammation by secreting both pro and anti-inflammatory cytokines. In numerous investigations, the role of cytokines in periodontitis has been examined. When it comes to promoting osteoclast activation, cytokines including GMCSF, IL-1 beta, IL-6, IL-17, and TNF-alpha are among the more crucial pro-inflammatory mediators. However, a significant gap exists in this field because the majority of studies have focused on anti-inflammatory cytokines that control inflammation by acting on Th1 and Th2 cells (IL-4, IL-10, IL13 etc.) and there are very few research focused on how anti-inflammatory interleukins affect Treg cells (IL-35) Finding clinical diagnostic and prognostic cutoff values for interleukins is problem number. Future research is warranted given the paucity of previous studies in this field in order to confirm diagnostic and prognostic recommendations and investigate recommendations for unstudied interleukin-disease connections